Potassium Hydroxide → HCID 44199846, compound

Participants

Reaction Steps

A solution of (4-benzyloxy-1-methyl-cyclohexyl)-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone (13 mg, 0.03 mmol), KOH (1 mg, 0.02 mmol), and 10% Pd/C (10 mg), in EtOH (8 ml), was hydrogenated for 2 days under H2 atmosphere (1 atm). The reaction mixture was filtered through a plug of celite using THF and DCM. The filtrate was concentrated to a white solid, which was purified by silica gel chromatography using 0-70% Et2O in DCM as eluant providing 9 mg (82%) of (4-benzyloxy-1-methyl-cyclohexyl)-(5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone as a white solid. M+H=350.

Provenance & Evidence