Tetrahydrofuran → HCID 57904164, compound

Participants

Reaction Steps

To a mixture of methyl 2-(2-(3,4-dichlorophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-acetate (14.84 g, 33.2 mmol), THF (200 ml) and water (120 ml) was a and stirred at room temperature. After 4 h, aqueous NaOH solution (6 M, 60 ml) was again added, and stirring was carried out overnight at room temperature. The reaction solution was concentrated under reduced pressure. 6 M HCl solution (125 ml) and DCM (400 ml) were added. After phase separation, the organic phase was washed with saturated NaCl solution, dried (sodium sulfate) and concentrated. For purification, the product was recrystallised from 2-propanol.

Provenance & Evidence