反应详情

2-(2-(3,4-Dichloro-N-methylphenylsulfonamido)phenyl)acetic acid methyl ester (13.7 g, 34.26 mmol) was dissolved in a mixture of methanol/dioxane/4 M NaOH (15/4/1) (266 ml, 52.92 mmol NaOH), and then further 4 M NaOH (39.7 ml, 158.76 mmol) was added. The resulting clear solution was stirred overnight at room temperature and then concentrated in vacuo. The residue was taken up in ethyl acetate and washed with 0.5 M KHSO4. The aqueous phase was then extracted several times with ethyl acetate. The combined organic phases were washed with saturated NaCl solution, dried over sodium sulfate and concentrated.

1. concentrationconcentrated in vacuo
2. washwashed with 0.5 M KHSO4
3. extractionThe aqueous phase was then extracted several times with ethyl acetate
4. washThe combined organic phases were washed with saturated NaCl solution
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated