Trifluoroacetic acid → 2-(3,4-Dichloro-N-methylphenylsulfonamido)-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylic acid

Participants

Reaction Steps

TFA (30 ml, 404 mmol) was added to a solution of tert-butyl 2-(3,4-dichloro-N-methylphenylsulfonamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (8.00 g, 16.8 mmol) in DCM (100 ml), and stirring was carried out for 1 h at room temperature. The reaction mixture was concentrated, and the TFA that remained was removed with toluene, DCM and diethyl ether. The residue was washed twice with diisopropyl ether.

Provenance & Evidence