Methanol → Methyl indoline-2-carboxylate

Participants

Reaction Steps

Thionyl chloride (12.1 ml, 167.2 mmol) was added dropwise, with stirring and while cooling with ice, to a solution of indoline-2-carboxylic acid (24.8 g, 152.0 mmol) in methanol (500 ml). The reaction mixture was stirred overnight at 40° C. The reaction solution was concentrated and thionyl chloride residues were removed by dragging out with diethyl ether (3 times).

Provenance & Evidence