Methanol → Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

Participants

Reaction Steps

1-Amino-cyclohexanecarboxylic acid (49 g, 342 mmol) was added to a solution, cooled to 0° C., of thionyl chloride (49.6 ml, 684 mmol) in methanol (750 ml). The reaction mixture was stirred for 4 h under reflux and then overnight at room temperature. Then the mixture was heated again for 3 h under reflux and stirred overnight again at room temperature. The reaction solution was concentrated and the thionyl chloride residues were removed by dragging out with methanol and diethyl ether.

Provenance & Evidence