Methyl iodide → HCID 66755678, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 1-(4-methoxyphenylsulfonamido)cyclohexanecarboxylate (27 g, 82.5 mmol) was dissolved in acetone (450 ml), and K2CO3 (22.8 g, 165 mmol) was added thereto. Methyl iodide (10.3 ml, 165 mmol) was then added, and the suspension was heated overnight at 40° C. in a closed flask. Because the reaction was not yet complete (TLC monitoring, heptane/ethyl acetate 2:1), methyl iodide (7.7 ml, 124 mmol) was again added and stirring was carried out over the weekend at room temperature. Methyl iodide (2.6 ml, 41.8 mmol) was again added, and stirring was carried out overnight at 40° C. After cooling, the solid materials were filtered off and the filtrate was concentrated to dryness. The crude product was used further without being purified further.

Provenance & Evidence