HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Phenylenediamine → Methyl (3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | Diethyl Maleate | HCID 5271566 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | Methyl (3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetate | HCID 21027845 | — |
Reaction Steps
Orthophenylenediamine (10 g, 92.4 mmol) and diethyl maleate (45 g, 646.8 mmol) were refluxed for 75 h in propanol. The solvent was removed using a rotary evaporator and the residue was purified by column chromatography (ethyl acetate/hexane 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119633B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-0f075b1158374d678740c17b3e90ed28 |
| Source note | uspto-grants-2012_02 |