HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-chloro-3-methylpyridine → tert-butyl (3aS,6aS)-5-(6-chloro-5-methyl-3-pyridinyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-chloro-3-methylpyridine | HCID 285434 | — |
| Reactant | 1,1-Dimethylethyl (3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate | HCID 29949089 | — |
| Product | tert-butyl (3aS,6aS)-5-(6-chloro-5-methyl-3-pyridinyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate | HCID 86584376 | 41% |
Reaction Steps
The product from Example 15E and 5-bromo-2-chloro-3-methylpyridine were processed as described in Example 1E to provide the title compound (41% yield). MS (DCI/NH3) m/z 338/340 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119635B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-0c65e10edfbf4183897f6d67b569c9a4 |
| Source note | uspto-grants-2012_02 |