HRID16423

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccnc4c3ccn4S(=O)(=O)c3ccc(C)cc3)c(F)c2)cc1

HCID17979281

未命名化合物

PRODUCTS

生成物

HCID17979343

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

50 mg (0.09 mmol) of N-[3-fluoro-4-({1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)phenyl]-4-methylphenylsulfonamide (from example XLIV) are dissolved in 30 ml of methanol, and 48.2 mg (0.05 mmol) of 10% palladium on activated carbon are added. The mixture is hydrogenated overnight under a hydrogen pressure of 3.5 bar. The palladium is then filtered off with suction through kieselguhr and washed with ethanol, and the filtrate is concentrated.

WORKUP

后处理

filtrationThe palladium is then filtered off with suction through kieselguhr
washwashed with ethanol
concentrationthe filtrate is concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f2cd3a689cc460385aac995c689043b
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07737153B2
来源说明: uspto-grants-2010_06

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([NH:28][S:29]([C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)(=[O:31])=[O:30])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[N:15]([S:18]([C:21]3[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=3)(=[O:20])=[O:19])[CH:16]=[CH:17][C:10]=12>CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([NH:28][S:29]([C:32]2[CH:33]=[CH:34][C:35]([CH3:38])=[CH:36][CH:37]=2)(=[O:30])=[O:31])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[N:15]([S:18]([C:21]3[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=3)(=[O:20])=[O:19])[CH2:16][CH2:17][C:10]=12