反应详情

To a solution of 3-(2-Nitro-benzoylamino)-1H-furo[3,2-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide (1 g, 0.0023 mol) in ethanol (30 mL) tin chloride dihydrate (2.08 g, 0.00923 mol) was added. The mixture was heated to reflux for 4 hours. After cooling, the solvent was evaporated to dryness and the crude purified by flash column chromatography on silica gel (eluting with dichloromethane-methanol 4713. The isolated product was triturated with ethyl ether and dry under vacuum, furnishing 550 mg of the title compound (59% yield).

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 hours
3. temperatureAfter cooling
4. customthe solvent was evaporated to dryness
5. customthe crude purified by flash column chromatography on silica gel (
6. washeluting with dichloromethane-methanol 4713
7. customThe isolated product was triturated with ethyl ether
8. customdry under vacuum