1,2-Diaminocyclohexane, (+)- → HCID 57619826, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-methyl-4-(4-oxo-1-piperidyl)piperidine-1-carboxylate (2.96 g, 10.0 mmol) and (1S,2S)-cyclohexane-1,2-diamine (2.29 g, 20.0 mmol) in dichloromethane (80 mL) was added sodium triacetoxyborohydride (3.18, 15.0 mmol) and stirred at room temperature for 12 h. Saturated NaHCO3 (40 mL) was added, phases were separated and the aqueous layer was extracted with dichloromethane (2×60 mL). The combined organic phases were washed with brine, dried over Na2SO4 and concentrated in vacuo to afford the title compound, which was used for the subsequent step without further purification.

Provenance & Evidence