1,2-Diaminocyclohexane, trans- → HCID 57619817, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-methyl-4-(4-oxo-1-piperidyl)piperidine-1-carboxylate (2.0 g, 6.76 mmol) and (1R,2R)-cyclohexane-1,2-diamine (1.55 g, 13.5 mmol) in dichloromethane (60 mL) was added sodium triacetoxyborohydride (2.12 g, 10.0 mmol) and stirred at room temperature for 12 h. Saturated NaHCO3 (40 mL) was added, the phases were separated and the aqueous phase was extracted with dichloromethane (2×60 mL). The combined organic phases were washed with brine, dried over Na2SO4, and concentrated in vacuo. The crude product was used for the next step without further purification.

Provenance & Evidence