1,2-Diaminocyclohexane, trans- → HCID 57619797, compound

HRID 1642487Notes

Reaction equation

HRID 1642487 reaction equation
[CH3:1][C:2]1([N:14]2[CH2:19][CH2:18][C:17](=O)[CH2:16][CH2:15]2)[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[CH2:21]1[CH2:26][C@@H:25]([NH2:27])[C@H:24]([NH2:28])[CH2:23][CH2:22]1>>[NH2:27][C@@H:25]1[CH2:26][CH2:21][CH2:22][CH2:23][C@H:24]1[NH:28][CH:17]1[CH2:18][CH2:19][N:14]([C:2]2([CH3:1])[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 438061,2-Diaminocyclohexane, trans-HCID 57619795HCID 57619795, compound

Product 1

HCID 57619797HCID 57619797, compound

Procedure

Following the procedure used in step D of the example 7 and starting with tert-butyl 3-methyl-3-(4-oxo-1-piperidyl)pyrrolidine-1-carboxylate (300 mg, 1.06 mmol) and 1R,2R-diaminocyclohexane (244.2 mg, 2.12 mmol), the title compound was obtained (300 mg). MS (M+1): 381.30

Sources & evidence

ORD record
ord-29b5cf1876984a06984ece0667911fa3
Source dataset
uspto-grants-2012_02
Patent number
US08119661B2

Reaction notes

Loading…