1,2-Diaminocyclohexane, cis- → HCID 66757269, compound

Participants

Reaction Steps

To a solution of cis-cyclohexane-1,2-diamine (0.850 mL, 7.22 mmol) in dichloromethane (10 mL) was added with tert-butyl 4-methyl-4-(4-oxo-1-piperidyl)piperidine-1-carboxylate (1.39 g, 3.61 mmol) in dichloromethane (5 mL) followed by sodium triacetoxyborohydride (0.918 g, 4.33 mmol) and the mixture stirred at room temperature over night. The mixture was then quenched with 1 N NaOH and dichloromethane was added. The phases were separated and aqueous phase was extracted with dichloromethane. The combined organic phases were dried and concentrated in vacuo to give the title product, which was used for the subsequent step without further purification. MS (M+1): 395.37.

Provenance & Evidence