Diisopropylethylamine → HCID 57619803, compound

Participants

Reaction Steps

A solution of 2-[(1R,2S)-2-[[1-[4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-piperidyl]-4-piperidyl]amino]cyclohexyl]acetic acid, diisopropylethylamine (0.5 mL, 3.36 mmol) and HATU (0.7 g, 1.84 mmol) in DMF (10 mL) was stirred at room temperature overnight. The reaction quenched with water and concentrated in vacuo. The residue was diluted in ethylacetate (100 mL) and washed with 1N NaOH (10 mL). The organic phase was separated and aqueous phase was extracted with ethylacetate (2×30 mL). The combined organic phases were dried and concentrated in vacuo to provide the title compound. MS (M+1): 420.38.

Provenance & Evidence