反应详情

4-Bromo-1H-indole-3-carbaldehyde (4.0 g, 17.8 mmol) was stirred in acetic anhydride (20 mL) at reflux for 4 h. The reaction was cooled and concentrated in vacuo. Cold MeOH was added to precipitate a white solid, which was collected by filtration to give 3.5 g (74%) of 1-acetyl-4-bromo-1H-indole-3-carbaldehyde. MS (ES) [m+H] calc'd for C11H8BrNO2, 266, 268; found 266, 268.

1. temperatureat reflux for 4 h
2. temperatureThe reaction was cooled
3. concentrationconcentrated in vacuo
4. additionCold MeOH was added
5. customto precipitate a white solid, which
6. filtrationwas collected by filtration