HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1642540Generated: November 1, 2026
Einecs 211-027-4 → 5-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carbonitrile
https://huagongshe.com/reaction/1642540
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Einecs 211-027-4 | HCID 69401 | — |
| Reactant | 3,5-Diamino-4-(2-fluoro-5-methyl-pyridin-3-yl)-benzonitrile | HCID 58880056 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carbonitrile | HCID 16124311 | 87% |
Reaction Steps
Compound 123 (148 mg, 0.61 mmol) was dissolved in dioxane (2 mL) with pyridinium chloride (80 mg), and the solution was heated at 180° C. in the microwave for 15 minutes. The solution was concentrated in vacuo. Purification by flash chromatography (20% acetone/CH2Cl2) gave 118 mg (87%) of the title compound as an off-white solid. MS (ES) [m+H] calc'd for C13H10N4, 223; found 223.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08119655B2 |
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| Source dataset | uspto-grants-2012_02 |
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| ORD ID | ord-2ce6133bc03f49c5a63b0fbe41f72d8b |
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| Source note | uspto-grants-2012_02 |
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