Trifluoroacetic acid → 5-(3-ethoxyphenyl)-3-methyl-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indole

Participants

Reaction Steps

The title compound was synthesized using an analogous procedure to that outlined in the preparation of Compound 176. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.35 (t, J=6.95 Hz, 3 H) 1.44-1.56 (m, 2 H) 2.10-2.18 (m, 1 H) 2.25 (br. s., 5 H) 2.80 (d, J=4.80 Hz, 3 H) 2.97-3.07 (m, 2 H) 3.52 (d, J=11.62 Hz, 2 H) 4.06-4.09 (m, 4 H) 6.98-7.14 (m, 5 H) 7.44 (t, J=7.71 Hz, 1 H) 7.64 (s, 1 H) 8.25 (s, 1 H) 9.28 (br. s., 1 H) 11.87 (s, 1 H); [M+H] calc'd for C27H32N3O2, 430.2; found, 430.5; [M+H+TFA] calc'd for C29H33N3O4F3, 544.2; found, 544.4.

Provenance & Evidence