反应详情

The title compound was synthesized from Compound 157 and 3-bromopropionitrile using an analogous procedure to that outlined in the preparation of Compound 205.1H NMR (400 MHz, MeOD) δ ppm 1.28 (d, J=14.65 Hz, 2 H) 1.28 (s, 2 H) 2.30 (s, 3 H) 3.10 (t, J=6.69 Hz, 2 H) 5.12 (t, J=6.82 Hz, 2 H) 7.00-7.05 (m, 2 H) 7.53 (dd, J=2.02, 0.76 Hz, 1 H) 7.81 (t, J=7.45 Hz, 1 H) 7.92 (ddd, J=7.89, 1.45, 1.26 Hz, 1 H) 8.02 (dt, J=7.83, 1.52 Hz, 1 H) 8.10 (t, J=1.89 Hz, 1 H) 8.26 (d, J=2.02 Hz, 1 H) [M+H] calc'd for C23H21N3O3S, 421; found, 421.