反应详情

The title compound was prepared from Compound 244 by using an analogous procedure to that outlined in the preparation of Compound 241. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.55 (m, 2 H) 0.68 (m, 2 H) 0.81 (br. m, 4 H) 2.17 (m, 1 H) 2.23 (s, 3 H) 2.87 (m, 1 H) 3.94 (s, 3 H) 7.40 (s, 1 H) 7.63 (t, J=7.71 Hz, 1 H) 7.72-7.71 (m, 2H) 7.94 (d, J=7.58 Hz, 1 H) 8.01 (s, 1 H) 8.21 (d, J=1.77 Hz, 1 H) 8.54 (d, J=4.04 Hz, 1 H) 9.84 (s, 1 H) 12.00 (s, 1 H); [M+H] calc'd for C27H27N4O3, 455.2; found, 455.4.