HRID1642594

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3874247

3-(Cyclopropylaminocarbonyl)phenylboronic acid

C10H12BNO3

结构：Cc1cnc2[nH]c3c(C)c(C(=O)NC4CCN(C)CC4)cc(Cl)c3c2c1

HCID16124308

5-Chloro-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide

C20H23ClN4O

PRODUCTS

生成物

结构：Cc1cnc2[nH]c3c(C)c(C(=O)NC4CCN(C)CC4)cc(-c4cccc(C(=O)NC5CC5)c4)c3c2c1

HCID25017261

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized from 5-chloro-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide and 3-(cyclopropylcarbamoyl)phenylboronic acid using an analogous procedure to that described in the preparation of compound 83. [M+H] calc'd for C30H33N5O2, 496.3.; found, 496.5.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16e2939e711f461ebfcea4e75bbf7202
来源数据集: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08119655B2
来源说明: uspto-grants-2012_02

反应 SMILES

Cl[C:2]1[CH:10]=[C:9]([C:11]([NH:13][CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)=[O:12])[C:8]([CH3:21])=[C:7]2[C:3]=1[C:4]1[CH:25]=[C:24]([CH3:26])[CH:23]=[N:22][C:5]=1[NH:6]2.[CH:27]1([NH:30][C:31]([C:33]2[CH:34]=[C:35](B(O)O)[CH:36]=[CH:37][CH:38]=2)=[O:32])[CH2:29][CH2:28]1>>[CH:27]1([NH:30][C:31]([C:33]2[CH:38]=[C:37]([C:2]3[CH:10]=[C:9]([C:11]([NH:13][CH:14]4[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]4)=[O:12])[C:8]([CH3:21])=[C:7]4[C:3]=3[C:4]3[CH:25]=[C:24]([CH3:26])[CH:23]=[N:22][C:5]=3[NH:6]4)[CH:36]=[CH:35][CH:34]=2)=[O:32])[CH2:28][CH2:29]1