HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58880180, compound → 4-(2-(3-chloro-5-(3-(ethylsulfonyl)phenyl)-9H-pyrido[2,3-b]indol-8-yloxy)ethyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58880180 | HCID 58880180 | — |
| Reactant | 3-(5-(3-(ethylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)-N,N-dimethylpropan-1-amine | HCID 58880181 | — |
| Product | 4-(2-(3-chloro-5-(3-(ethylsulfonyl)phenyl)-9H-pyrido[2,3-b]indol-8-yloxy)ethyl)morpholine | HCID 58880196 | — |
Reaction Steps
The title compound was prepared from Compound 218 by using an analogous procedure to that outlined in the preparation of Compound 205. 1H NMR (400 MHz, Methanol-d4) δ 8.12 (s, 1 H) 8.00(m, 1 H) 7.92 (m, 1 H) 7.74 (t, J=7.84 Hz, 1 H) 7.64 (s, 1 H) 7.09 (m, 1 H) 7.02 (m, 1 H) 6.84 (s, 1 H) 4.40 (t, J=5.0 Hz, 2 H) 4.11 (br, 4 H) 3.80 (br, 4 H) 3.55 (t, J=5.0 Hz, 2 H) 3.30 (q, J=7.32 Hz, 2 H) 1.27 (t, J=7.32 Hz, 3 H). [M+H] calc'd for C25H27ClN3O4S, 500; found, 500.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119655B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-d1b59056243341d8bf68691f359e0064 |
| Source note | uspto-grants-2012_02 |