Triphenylphosphine → HCID 66756812, compound

Participants

Reaction Steps

To a solution of N-(t-butoxycarbonylsulfamoyl)-N-(2-benzyloxy-4-iodophenyl)glycine tert-butyl ester (3.49 g, 5.6 mmol) in toluene (224 mL) is added triphenylphosphine (2.22 g, 8.47 mmol) and 2-trimethylsilanylethanol (992 mg, 8.38 mmol). DIAD (1.6 mL, 8.13 mmol) is then added dropwise over 10 min. After it is stirred for 50 min., toluene is remove under reduced pressure. After 18 h, 20% EtOAc/hexane is added (50 mL in 4 increments) to form a precipitate. The solid is filtered out and the filtrate is then concentrated. The residue is then purified by column chromatography to give the title compound as a white foam.

Provenance & Evidence