Hydrochloric Acid → HCID 66757008, compound

Participants

Reaction Steps

To a solution of 5-[4-(2-aminobenzyl)-2-benzyloxyphenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (150 mg, 0.29 mmol) in pyridine (3 mL) is added α-tolylsulfonyl chloride (66 mg, 0.35 mmol) and the solution is stirred at ambient temperature for 1.5 h. The mixture is neutralized using 1N HCl solution, then diluted with EtOAc. The organic phase is washed with brine and water and is dried with MgSO4, and concentrated. The residue is purified by flash column chromatography to give the title compound.

Provenance & Evidence