Methanesulfonyl chloride → HCID 17747431, compound

HRID 1642607Notes

Reaction equation

[NH2:1][C:2]1[C:3]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[S:23](=[O:25])(=[O:24])[N:22](CC[Si](C)(C)C)[C:21](=[O:32])[CH2:20]3)=[C:15]([O:33]CC3C=CC=CC=3)[CH:14]=2)=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:41][S:42](Cl)(=[O:44])=[O:43]>>[OH:33][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[N:19]1[CH2:20][C:21](=[O:32])[NH:22][S:23]1(=[O:25])=[O:24])[CH2:12][C:3]1[C:2]([NH:1][S:42]([CH3:41])(=[O:44])=[O:43])=[CH:11][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 66756819HCID 66756819, compound

Product 1

HCID 17747431HCID 17747431, compound

Procedure

N-{3-[3-Hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-naphthalen-2-yl}-methanesulfonamide is prepared analogously to Example 4, Steps B and C, starting with 5-[4-(3-aminonaphthalen-2-ylmethyl)-2-benzyloxyphenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and methanesulfonyl chloride: MS (M−H)−=460.

Sources & evidence

ORD record: ord-22b71cbc10e84cdeafc9ca4134221f0f
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119666B2

Reaction notes

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