HCID 66756613, compound → HCID 66756638, compound

Participants

Reaction Steps

A solution of 5-(2-benzyloxy-4-phenoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one potassium salt (0.30 g, 0.67 mmol) in water (10 mL) is hydrogenated at 1 atm over 10% Pd/C (0.05 g) for 24 h. The catalyst is filtered and the water removed by lyophilization to afford the product, 5-(2-hydroxy-4-phenoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one potassium salt, as an amorphous pale-grey solid: mp=205-210° C.; 1H NMR (DMSO-d6) δ 9.52 (br s, 1H), 7.47-7.41 (m, 3H), 7.19 (t, 1H), 7.08 (d, J=7.57 Hz, 2H), 6.51 (d, J=2.78 Hz, 1H), 6.46 (dd, J=8.59, 2.78 Hz, 1H), 4.06 (s, 2H); MS (M−H)−=319.

Provenance & Evidence