Benzyl Bromide → 3-(Benzyloxy)-4-nitrobenzaldehyde

Participants

Reaction Steps

To a stirred solution of benzyl bromide (6.9 g, 40.3 mmol) and 3-hydroxy-4-nitrobenzaldehyde (9.7 g, 58.0 mmol) is added K2CO3 (8.9 g, 64.4 mmol). The mixture is stirred at ambient temperature overnight, diluted with water and extracted with EtOAc. The organic phase is washed with aqueous K2CO3 and brine, dried over MgSO4, filtered and concentrated to afford 3-benzyloxy-4-nitrobenzaldehyde as a yellow solid: MS (M+H)+=258.

Provenance & Evidence