HCID 59850300, compound → HCID 86625048, compound

HRID 1642640Notes

Reaction equation

HRID 1642640 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13](I)[CH:12]=[CH:11][C:10]=1[N:16]([S:25]([N:28]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])(=[O:27])=[O:26])[CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[K].C(C1C=CC(N2S(=O)(=O)NC(=O)C2)=C(O)C=1)C1C=CC=CC=1.OC1C=C(C=CC=1N1CC(=O)NS1(=O)=O)[CH2:69][C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][C:71]=1[O:76][S:77]([CH3:80])(=[O:79])=[O:78]>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:69][C:70]2[CH:75]=[CH:74][CH:73]=[CH:72][C:71]=2[O:76][S:77]([CH3:80])(=[O:79])=[O:78])[CH:12]=[CH:11][C:10]=1[N:16]([S:25]([N:28]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])(=[O:27])=[O:26])[CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 59850300HCID 59850300, compound2×HCID 66756811HCID 66756811, compoundHCID 66756812HCID 66756812, compound

Product 1

HCID 86625048HCID 86625048, compound

Procedure

The title compound is prepared analogously to Example 1, Step I, starting with (tert-butyl N-[2-(benzyloxy)-4-iodophenyl]-N-({(tert-butoxycarbonyl)[2-(trimethylsilyl)ethyl]amino}-sulfonyl)glycinate) (intermediate from Example 1) and methanesulfonic acid 2-iodomethylphenyl ester (intermediate from Example 18).

Sources & evidence

ORD record
ord-2bc2e580c92e432c8d6a04b92ce7645a
Source dataset
uspto-grants-2012_02
Patent number
US08119666B2

Reaction notes

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