反应详情

To a mixture of 2-benzyloxy-6-methylphenylamine (3.4 g, 16 mmol) in MeOH (50 mL) and AcOH (20 mL) is added Br2 (0.82 mL, 16 mmol) in AcOH (10 mL) at 0° C. The mixture is then stirred at ambient temperature for 18 h. The solvent is then removed under reduced pressure. Then K2CO3 solution is added followed by EtOAc. The organic layer is washed with water and brine, dried and concentrated. The residue is then purified by flash chromatography to give the title compound as a red liquid.

1. customThe solvent is then removed under reduced pressure
2. additionThen K2CO3 solution is added
3. washThe organic layer is washed with water and brine
4. customdried
5. concentrationconcentrated
6. customThe residue is then purified by flash chromatography