2-Chloro-N,N-dimethylethylamine → HCID 74387732, compound

HRID 1642745Notes

Reaction equation

HRID 1642745 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:24])[F:23])=[C:11]([F:28])[CH:10]=2)[S:3]1.Cl[CH2:30][CH2:31][N:32]([CH3:34])[CH3:33]>>[CH3:33][N:32]([CH3:34])[CH2:31][CH2:30][N:6]1[C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:23])[F:24])=[C:11]([F:28])[CH:10]=2)[S:3][C:2]1=[O:1]

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 74387388HCID 74387388, compound

Product 1

HCID 74387732HCID 74387732, compound

Procedure

The title compound was prepared using 4-[4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-2-fluoro-phenoxy]-3-trifluoromethyl-benzonitrile and (2-Chloro-ethyl)-dimethyl-amine as described in Example 1. 1H NMR (400 Hz, CDCl3) δ7.95 (s, 1H), 7.76 (s, 1H), 7.69 (dd, 1H), 7.27 (m, 3H), 6.84 (d, 1H), 3.91 (t, 2H), 2.76 (bt, 2H), 2.40 (s, 6H); LC/MS (m/z) [M+1]+ 480.1 (calculated for C22H18F4N3O3S, 480.45).

Sources & evidence

ORD record
ord-11b46325b9b34b8ba72445118a7211ee
Source dataset
uspto-grants-2012_02
Patent number
US08119669B2

Reaction notes

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