1-(2-Chloroethyl)pyrrolidine → HCID 74387728, compound

HRID 1642747Notes

Reaction equation

HRID 1642747 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:24])[F:23])=[C:11]([F:28])[CH:10]=2)[S:3]1.Cl[CH2:30][CH2:31][N:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[O:1]=[C:2]1[N:6]([CH2:30][CH2:31][N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)[C:5](=[O:7])[C:4](=[CH:8][C:9]2[CH:27]=[CH:26][C:12]([O:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[C:22]([F:25])([F:23])[F:24])=[C:11]([F:28])[CH:10]=2)[S:3]1

Participants

3

Reactant 2

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 74387388HCID 74387388, compound

Product 1

HCID 74387728HCID 74387728, compound

Procedure

The title compound was prepared using 4-[4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-2-fluoro-phenoxy]-3-trifluoromethyl-benzonitrile and 1-(2-Chloro-ethyl)-pyrrolidine as described in Example 1. 1H NMR (400 Hz, DMSO-d6) δ8.49 (s, 1H), 8.21 (dd, 1H), 8.05 (s, 1H), 7.87 (d, 1H), 7.64 (m, 2H), 7.31 (d, 1H), 3.86 (t, 2H), 2.76 (bs, 2H), 2.60 (bs, 4H), 1.73 (bs, 4H); LC/MS (m/z) [M+1]+ 506.2 (calculated for C24H20F4N3O3S, 506.49).

Sources & evidence

ORD record
ord-c0ce76763ce4477fb7bb3ab7e0cba00b
Source dataset
uspto-grants-2012_02
Patent number
US08119669B2

Reaction notes

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