Ethanol → 2-chloro-N-(5-methyl-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidin-4-amine

HRID 164276Notes

Reaction equation

HRID 164276 reaction equation
[CH3:13][c:14]1[cH:15][c:16]([NH2:19])[n:17][nH:18]1.[CH3:26][CH2:27][OH:28].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:9]([F:10])([F:11])[F:12])[c:6]([Cl:8])[n:7]1.[Na+:20].[Na+:21].[O-:22][C:23](=[O:24])[O-:25]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([C:9]([F:10])([F:11])[F:12])[c:6]([NH:19][c:16]2[cH:15][c:14]([CH3:13])[nH:18][n:17]2)[n:7]1

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 27827742,4-Dichloro-5-(trifluoromethyl)pyrimidine

Product 1

HCID 582551692-chloro-N-(5-methyl-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidin-4-amine

Sources & evidence

ORD record
ord-83cf5f11a2a44aaa91d571e3c3b6874d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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