Ethyl 5-bromopyridine-3-carboxylate → HCID 58002554, compound

HRID 1642786Notes

Reaction equation

HRID 1642786 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:12]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8].[CH2:13]([C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1)[CH3:14]>>[CH2:13]([C:15]1[CH:20]=[CH:19][C:18]([C:2]2[CH:12]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:5]=[N:4][CH:3]=2)=[CH:17][CH:16]=1)[CH3:14]

Participants

3

Reactant 2

HCID 140785Ethyl 5-bromopyridine-3-carboxylateHCID 2734352Boronic acid, (4-ethylphenyl)-

Product 1

HCID 58002554HCID 58002554, compound

Procedure

29 g (126 mmol) of ethyl 5-bromonicotinate and 23 g (152 mmol, 1.2 eq.) of 4-ethylphenylboronic acid were reacted according to the General Method 1A. Yield: 32 g (82% of theory)

Sources & evidence

ORD record
ord-e27bc0f9faec479984ff556bc69d175f
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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