HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 1-(cyclopentylcarbonyl)-5-[4-(1-methylethyl)phenyl]piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclopentanecarbonyl chloride | HCID 78284 | — |
| Reactant | Ethyl 5-[4-(1-methylethyl)phenyl]piperidine-3-carboxylate | HCID 58002566 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 1-(cyclopentylcarbonyl)-5-[4-(1-methylethyl)phenyl]piperidine-3-carboxylate | HCID 58002165 | — |
Reaction Steps
1.5 g (5.3 mmol) of ethyl 5-[4-(1-methylethyl)phenyl]piperidine-3-carboxylate were dissolved in 18 ml of dichloromethane, and 0.81 g (7.9 mmol) of triethylamine was added at 0° C. 1.43 g (10.5 mmol) of cyclopentanecarbonyl chloride were then added dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-a5761259acf34cc0b616d8a0b6043194 |
| Source note | uspto-grants-2012_02 |