Lithium Hydroxide → HCID 58002156, compound

Participants

Reaction Steps

99 ml of dioxane, 50 ml of water and 1.37 g (57.0 mmol) of lithium hydroxide were added to 5.9 g (14.3 mmol) of ethyl 1-(cyclopentylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate. The mixture was stirred at RT overnight. For work-up, the dioxane was removed under reduced pressure, water was added to the reaction mixture and the mixture was acidified using aqueous 1 N hydrochloric acid solution. The mixture was extracted with dichloromethane. The organic phase was dried with sodium sulphate and concentrated under reduced pressure. Yield: 5.3 g (95% of theory)

Provenance & Evidence