4-Morpholinecarbonyl chloride → Ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

HRID 1642807Notes

Reaction equation

HRID 1642807 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[N:20]1([C:26](Cl)=[O:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][N:13]([C:26]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[O:27])[CH2:12][CH:11]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10]2)=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 58002384Ethyl 5-(4-ethylphenyl)piperidine-3-carboxylate

Product 1

HCID 58002205Ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

Procedure

10.0 g (36.0 mmol) of ethyl 5-(4-ethylphenyl)piperidine-3-carboxylate and 7.0 g (46.8 mmol, 1.3 eq.) of morpholine-4-carbonyl chloride were reacted according to the General Method 3A. Yield: 12.0 g (89% of theory)

Sources & evidence

ORD record
ord-0f6bd79ac2fc41448574bde6b793dc6e
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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