HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidinecarbonyl chloride → Methyl 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidinecarbonyl chloride | HCID 70937 | — |
| Reactant | Methyl 5-(4-ethylphenyl)piperidine-3-carboxylate | HCID 58002552 | — |
| Product | Methyl 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylate | HCID 58002473 | — |
Reaction Steps
6.7 g (24.1 mmol) of methyl 5-(4-ethylphenyl)piperidine-3-carboxylate and 4.2 g (31.4 mmol, 1.3 eq.) of pyrrolidine-1-carbonyl chloride were reacted according to the General Method 3A. Yield: 7.6 g (91% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-baf3d19ade9e426882e7eb44643da53d |
| Source note | uspto-grants-2012_02 |