HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Morpholinecarbonyl chloride → Methyl 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Morpholinecarbonyl chloride | HCID 84810 | — |
| Reactant | Methyl 5-(4-(trifluoromethoxy)phenyl)piperidine-3-carboxylate | HCID 58002737 | — |
| Product | Methyl 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylate | HCID 58002544 | — |
Reaction Steps
8.3 g (26.5 mmol) of methyl 5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylate and 5.2 g (34.5 mmol, 1.3 eq.) of morpholine-4-carbonyl chloride were reacted according to the General Method 3A. Yield: 11.0 g (100% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-6ebf7d7b0d9e44b2a84e0a230d91baa5 |
| Source note | uspto-grants-2012_02 |