HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate | HCID 58002139 | — |
| Product | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid | HCID 58002447 | — |
Reaction Steps
22.19 g (39.90 mmol) of the compound from Example 48A and 44.78 g (399.0 mmol) of potassium tert-butoxide were reacted according to the General Method 9A. Yield: 18.29 g (100% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-c0979e2cd5ca440d8e5d7ecaad3dc51c |
| Source note | uspto-grants-2012_02 |