HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 1-[(3-hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylate | HCID 58002428 | — |
| Product | 1-[(3-Hydroxypyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002490 | — |
Reaction Steps
26.05 g (16.06 mmol) of the compound from Example 111A were reacted with 26.05 g (160.6 mmol) of potassium tert-butoxide according to the General Method 9A. Yield: 5.9 g (91% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-ba76c32274f94b82994cb6b7e4570277 |
| Source note | uspto-grants-2012_02 |