Lawesson's reagent → HCID 58002347, compound

HRID 1642831Notes

Reaction equation

HRID 1642831 reaction equation
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:28]([NH2:30])=O)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:40])=CC=1>>[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:14][CH:13]([C:28](=[S:40])[NH2:30])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 58002282HCID 58002282, compound

Product 1

HCID 58002347HCID 58002347, compound

Procedure

1.50 g (3.53 mmol) of the compound from Example 116A and 786 mg (1.94 mmol) of Lawesson reagent were reacted according to the General Method 10A. Yield: 1.34 mg (39% of theory, 45% pure)

Sources & evidence

ORD record
ord-677ccd4fd5734c939740868f88cfcdce
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…