Lawesson's reagent → HCID 58002396, compound

HRID 1642837Notes

Reaction equation

HRID 1642837 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23]([NH2:25])=O)[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:35])=CC=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](=[S:35])[NH2:25])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 58002433HCID 58002433, compound

Product 1

HCID 58002396HCID 58002396, compound

Procedure

910 mg (2.63 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxamide (Example 139A) and 586 mg (1.45 mmol) of Lawesson reagent were reacted according to the General Method 10A. Yield: 849 mg (89% of theory).

Sources & evidence

ORD record
ord-74a0d4f082794a1085d68e22564df3a2
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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