Ethyl bromopyruvate → HCID 58002411, compound

HRID 1642839Notes

Reaction equation

[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](=[S:25])[NH2:24])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].Br[CH2:27][C:28](=O)[C:29]([O:31][CH2:32][CH3:33])=[O:30]>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23]3[S:25][CH:27]=[C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[N:24]=3)[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

Reactant 2

HCID 66144Ethyl bromopyruvate

HCID 58002396HCID 58002396, compound

Product 1

HCID 58002411HCID 58002411, compound

Procedure

850 mg of the compound from Example 140A and 550 mg (2.82 mmol) of ethyl 3-bromo-oxopropanoate were reacted according to the General Method 3. Yield: 150 mg (12% of theory).

Sources & evidence

ORD record: ord-9681f333e86f46cdbb4ae3948e50c177
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

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