HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromopyridine-3-carboxylate → Methyl 5-[4-methyl-3-(trifluoromethyl)phenyl]pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Reactant | [4-Methyl-3-(trifluoromethyl)phenyl]boronic acid | HCID 45158669 | — |
| Product | Methyl 5-[4-methyl-3-(trifluoromethyl)phenyl]pyridine-3-carboxylate | HCID 58002360 | — |
Reaction Steps
2.2 g (10.3 mmol) of methyl 5-bromonicotinate and 2.5 g (12.4 mmol) of [4-methyl-3-(trifluoromethyl)phenyl]boronic acid were reacted according to the General Method 1A. Yield: 2.6 g (86% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-0bbb90cdfa204df7936793569e0f9917 |
| Source note | uspto-grants-2012_02 |