HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromopyridine-3-carboxylate → Methyl 5-[3-methyl-4-(trifluoromethoxy)phenyl]pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Reactant | (3-Methyl-4-(trifluoromethoxy)phenyl)boronic acid | HCID 46739138 | — |
| Product | Methyl 5-[3-methyl-4-(trifluoromethoxy)phenyl]pyridine-3-carboxylate | HCID 58002517 | — |
Reaction Steps
2.7 g (12.5 mmol) of methyl 5-bromonicotinate and 3.3 g (15.0 mmol) of [3-methyl-4-(trifluoromethoxy)phenyl]boronic acid were reacted according to the General Method 1A. Yield: 3.1 g (80% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-b6eb256e09af422084beea3e367a1d1c |
| Source note | uspto-grants-2012_02 |