N'-Hydroxycyclopropanecarboximidamide → HCID 58002146, compound

HRID 1642845Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[CH2:11][CH:10]([C:25](O)=[O:26])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O[N:29]=[C:30]([CH:32]1[CH2:34][CH2:33]1)[NH2:31]>>[CH:32]1([C:30]2[N:31]=[C:25]([CH:10]3[CH2:11][CH:12]([C:14]4[CH:15]=[CH:16][C:17]([O:20][C:21]([F:24])([F:22])[F:23])=[CH:18][CH:19]=4)[CH2:13][N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[O:7])[CH2:9]3)[O:26][N:29]=2)[CH2:34][CH2:33]1

Participants

Reactant 2

HCID 2794666N'-Hydroxycyclopropanecarboximidamide

HCID 58002271HCID 58002271, compound

Product 1

HCID 58002146HCID 58002146, compound

Procedure

1.00 g (2.57 mmol) of the compound from Example 173A and 386 mg (3.86 mmol) of the compound from Example 78A were reacted according to the General Method 2. Yield: 185 mg (16% of theory)

Sources & evidence

ORD record: ord-6f8c9539f39242a1bfa3c517efbab8c7
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

Loading…