N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine → HCID 58002628, compound

HRID 1642851Notes

Reaction equation

HRID 1642851 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=4)[CH2:16][NH:15][CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:30]([O:34][C:35]([NH:37][C:38]([CH3:43])([C:40](O)=[O:41])[CH3:39])=[O:36])([CH3:33])([CH3:32])[CH3:31]>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:27])[F:28])=[CH:21][CH:20]=4)[CH2:16][N:15]([C:40](=[O:41])[C:38]([NH:37][C:35](=[O:36])[O:34][C:30]([CH3:33])([CH3:32])[CH3:31])([CH3:43])[CH3:39])[CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2733845N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanineHCID 58002164HCID 58002164, compound

Product 1

HCID 58002628HCID 58002628, compound

Procedure

150 mg (0.30 mmol) of the compound from Example 178A and 66 mg (0.32 mmol) of N-(tert-butoxycarbonyl)-2-methylalanine were reacted according to the General Method 7. Yield: 117 mg (64% of theory)

Sources & evidence

ORD record
ord-7e18387dd95e48378d4e7c3ebbfe1ce0
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…