Methyl 5-bromopyridine-3-carboxylate → HCID 58002742, compound

HRID 1642853Notes

Reaction equation

HRID 1642853 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:12][C:13]([F:25])([F:24])[O:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[F:12][C:13]([F:24])([F:25])[O:14][C:15]1[CH:20]=[C:19]([C:2]2[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=[N:4][CH:3]=2)[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 699336Methyl 5-bromopyridine-3-carboxylateHCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 58002742HCID 58002742, compound

Procedure

2.61 g (12.09 mmol) of methyl 5-bromonicotinate and 2.49 g (12.09 mmol) of 3-(trifluoromethoxy)phenylboronic acid were reacted according to the General Method 1A. Yield: 2.44 g (68% of theory)

Sources & evidence

ORD record
ord-2d3cd22d44604d75b07fb330991e22d8
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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