HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxybenzenecarboximidamide → 4-{[3-(4-Ethylphenyl)-5-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]carbonyl}morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxybenzenecarboximidamide | HCID 69186 | — |
| Reactant | 5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58002225 | — |
| Product | 4-{[3-(4-Ethylphenyl)-5-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]carbonyl}morpholine | HCID 58002249 | — |
Reaction Steps
400 mg (1.16 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid (Example 38A) and 173 mg (1.27 mmol, 1.1 eq.) of N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 373 mg (72% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-da1d1d6f5a53487b9ab21a0fef0b3c70 |
| Source note | uspto-grants-2012_02 |